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ORIGINAL ARTICLE
Year : 2018  |  Volume : 4  |  Issue : 3  |  Page : 115-121

The evaluation of insertion and deletion polymorphism in population and personal identification amidst Chinese populations


1 Institute of Forensic Science, Ministry of Public Security, Beijing 100038, China
2 Department of Forensic Medicine, Nanjing Medical University, Nanjing, 210029; MOE Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, 200438; Fudan-Taizhou Institute of Health Sciences, Jiangsu, 225300, China
3 MOE Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, 200438; Fudan-Taizhou Institute of Health Sciences, Jiangsu, 225300, China
4 Department of Forensic Medicine, Nanjing Medical University, Nanjing, 210029, China

Correspondence Address:
Dr. Feng Chen
Department of Forensic Medicine, Nanjing Medical University, Nanjing 210029
China
Dr. Shilin Li
MOE Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, 200438, China; Fudan-Taizhou Institute of Health Sciences, Taizhou 225300
China
Dr. Wanshui Li
Institute of Forensic Science, Ministry of Public Security, Beijing 100038
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jfsm.jfsm_24_18

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For comprehensive understanding of practical application and evaluation on the power of 30 commonly used InDels (Qiagen Investigator DIPplex® kit), we captured population data from 25 Chinese populations and employed F-statistics for population genetics analysis. The results indicated that the distributions of allelic frequencies among populations were in different levels. Furthermore, the phylogeny conforming pairwise FSTdistances showed that the differentiation of majority populations were consistent with their geographic locations and historic dispersals. We conduct the comprehensive correlation analysis between FSTand heterozygosity of 30 InDel loci and provided strong evidence for ongoing InDel loci selection. The FSTvalues of 30 InDels were calculated within 25 Chinese populations, and then, these loci were characterized definitely based on their roles in population genetics or individual identification. Data indicated that 17 InDels with FST<0.01 could be utilized regarding Chinese individual identification (total discrimination power = 0.999985 and cumulative matching probability = 0.00000009). We comprehensively reconstructed the population structure and filled the gap of evaluating the ability of InDels in personal as well as population identification. The application of InDel loci in the forensic area would convincingly promote the development matter of forensic population identification and personal discrimination.


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