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ORIGINAL ARTICLE
Year : 2016  |  Volume : 2  |  Issue : 4  |  Page : 195-202

A Gold Nanoparticle-enhanced Surface Plasmon Resonance Aptasensor for the Detection of 2,4,6-trinitrotoluene


1 Collaborative Innovation Center of Judicial Civilization; People's Public Security University of China, Beijing 100038, China
2 Collaborative Innovation Center of Judicial Civilization; Key Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, Beijing 100088, China
3 People's Public Security University of China, Beijing 100038, China

Correspondence Address:
Hongxia Hao
Collaborative Innovation Center of Judicial Civilization, Beijing 100088; Key Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, Beijing 100088
China
Ruiqin Yang
People's Public Security University of China, Beijing 100038
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2349-5014.197934

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A gold nanoparticle-enhanced surface plasmon resonance (SPR) aptasensor was developed for high-specificity and high-sensitivity detection of 2,4,6-trinitrotoluene (TNT). Self-assembly film-forming technology was used to modify the gold surface of the sensor chip with 2,4,6-trinitrophenyl glycine, a TNT analogue, using polyethylene glycol to which the thiol group and carboxyl group are attached. Aptamer-gold nanoparticle complexes were formed through Au-S bonding. To detect TNT, the samples were incubated with the aptamer-gold nanoparticle complexes, and the solution competition method was applied through the SPR aptasensor. The results showed that the SPR aptasensor achieved fast, real-time detection of TNT. This gold nanoparticle-enhanced SPR aptasensor is suitable for TNT detection in the field of public safety and environmental monitoring.


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